Questions:
1. Which of the following is a correct statement about a shift of the oxyhemoglobin dissociation curve to the right?
a. It can result from an increase in blood ph.
b. It can result from an increase in body temperature.
c. It results in less oxygen being unloaded for a given pO2.
d. It results in 100% saturation of hemoglobin
2. Respiratory acidosis and a fever would result in which of the following changes in the oxyhemoglobin dissociation curve?
a. A shift to the right and increased saturation
b. A shift to the left and increased saturation
c. A shift to the left and decreased saturation
d. A shift to the right and decreased saturation
3. Which of the following factors would decrease the release of oxygen from hemoglobin at the tissue level?
a. core body temperature of 102.2 degrees fahr
b. arterial pH of 7.32
c. massive transfusion of stored banked blood
d. increased levels of 2,3 - DPG
Facts about the oxyhemoglobin dissociation curve. It explains the affinity of the oxygen to the hemoglobin.
A shift to the right results in unloading of oxygen to the tissues. Oxygen unbinds from the hemoglobin.
The four factors that shifts the oxyhemoglobin dissociation curve to the Right are:
a. increase temperature
b. metabolic acidosis
c. increase in pCO2
d. increase 2,3-DPG
A shift to the left results in oxygen binding tightly with the hemoglobin therefore oxygen does not get to the tissues.
The four factors that shifts the oxyhemoglobin dissociation curve to the Left are:
a. decrease temperature
b. metabolic alkalosis
c. decrease in pCO2
d. decrease 2,3 - DPG
What is 2,3 DPG - it is a metabolite called diphosphateglycerate. It is an adaptive mechanism, made in the red blood cell that controls movement of the oxygen from the red blood cells to the tissue. Increase in this substance shifts the curve to the right and unloads the oxygen into the tissues.
Answers:
1. b
2. a
3. c
The causes of shift to right can be remembered using the mnemonic, "CADET, face Right!" for CO2, Acid, 2,3-DPG, Exercise and Temperature.[1] Factors that move the oxygen dissociation curve to the right are those physiological states where tissues need more oxygen. For example during exercise, muscles have a higher metabolic rate, and consequently need more oxygen, produce more carbon dioxide and lactic acid, and their temperature rises.=from Wikkipedia
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